Feasibility of matching Vaccine Adverse Event Reporting System and poison center records.
Forrester MB. J Registry Manage 2013;40:93-97.
Background: The Vaccine Adverse Event Reporting System (VAERS) is a US surveillance program that collects information on adverse events that occur after the use of vaccines. Poison centers also receive calls about potentially adverse exposures to vaccines. Since the same vaccine exposure might be reported to both VAERS and a poison center, this study examined the feasibility of matching publicly available VAERS records to poison center records. Methods: All VAERS records reported from Texas during 2000 2011 were downloaded from the VAERS database. All vaccine exposures reported to Texas poison centers during 2000 2011 were identified. Since no unique identifiers (eg, names, dates of birth, etc) were available in the public VAERS database, matches had to be made using other, non unique data fields that both databases had in common. Matches were made using the following 4 data fields: vaccine, sex or gender, age, and date. The match rate was determined for total poison center records and for selected poison center variables. Results: There were 13,630 VAERS and 738 poison center records in the investigation. Twenty nine percent (213) of the poison center records were matched to VAERS records. The match rate by 3 year period was 2000 2002 (21%), 2003 2005 (27%), 2006 2008 (20%), and 2009 2011 (41%). The rate for the most common vaccines was influenza (42%), pneumococcal (39%), diphtheria pertussis tetanus (49%), hepatitis B (14%), and diphtheria tetanus (29%). The match rate was 35% for adverse reactions and 32% for therapeutic errors. The rate was 28% for non-serious outcomes and 33% for serious outcomes. The match rate was 29% for patients managed on site and 28% for patients already at or referred to a health-care facility. Conclusion: Matching between public VAERS and poison center records can be performed. However, these matches might be considered tentative because unique identifiers are not available. The match rate was highest during the most recent 3 year period. The match rate varied by vaccine but not by the exposure reason, management site, or medical outcome.
Prevalence and Correlates of Gastroschisis in 15 States, 1995 to 2005.
Kirby, Russell S. PhD, MS; Marshall, Jennifer MPH; Tanner, Jean Paul MPH; Salemi, Jason L. MPH; Feldkamp, Marcia L. PhD, PA; Marengo, Lisa MS; Meyer, Robert E. PhD; Druschel, Charlotte M. MD, MPH; Rickard, Russel MS; Kucik, James E. PhD, MPH; for the National Birth Defects Prevention Network
Obstetrics & Gynecology: epub 8 July 2013
Objective: To identify trends in the prevalence and epidemiologic correlates of gastroschisis using a large population-based sample with cases identified by the National Birth Defects Prevention Network over the course of an 11-year period. Methods: This study examined 4,713 cases of gastroschisis occurring in 15 states during 1995-2005, using public use natality data sets for denominators. Multivariable Poisson regression was used to identify statistically significant risk factors, and Joinpoint regression analyses were conducted to assess temporal trends in gastroschisis prevalence by maternal age and race and ethnicity. Results: Results show an increasing temporal trend for gastroschisis (from 2.32 per 10,000 to 4.42 per 10,000 live births). Increasing prevalence of gastroschisis has occurred primarily among younger mothers (11.45 per 10,000 live births among mothers younger than age 20 years compared with 5.35 per 10,000 among women aged 20 to 24 years). In the multivariable analysis, using non-Hispanic whites as the referent group, non-Hispanic black women had the lowest risk of having a gastroschisis-affected pregnancy (prevalence ratio 0.42, 95% confidence interval [CI] 0.37-0.48), followed by Hispanics (prevalence ratio 0.86, 95% CI 0.81-0.92). Gastroschisis prevalence did not differ by newborn sex. Conclusions: Our findings demonstrate that the prevalence of gastroschisis has been increasing since 1995 among 15 states in the United States, and that higher rates of gastroschisis are associated with non-Hispanic white maternal race and ethnicity, and maternal age younger than 25 years (particularly younger than 20 years of age).
The less than glorious side of morning glories.
Texas Public Health Journal 2013;65(3):5.
Pediatric ingestions of dissolvable nicotine products.
Texas Public Health Journal 2013;65(3):5-6.
Ask-Advise-Connect: A New Approach to Smoking Treatment Delivery in Health Care Settings.
Vidrine JI, Shete S, Cao Y, Greisinger A, Harmonson P, Sharp B, Miles L, Zbikowski SM, Wetter DW.
JAMA Intern Med. 2013 Mar 25; 173(6):458-64.
Importance: Several national health care-based smoking cessation initiatives have been recommended to facilitate the delivery of evidence-based treatments, such as quitline (telephone-based tobacco cessation services) assistance. The most notable examples are the 5 As (Ask, Advise, Assess, Assist, Arrange) and Ask. Advise. Refer. (AAR) programs. Unfortunately, rates of primary care referrals to quitlines are low, and most referred smokers fail to call for assistance. Objective: To evaluate a new approach--Ask-Advise-Connect (AAC)--designed to address barriers to linking smokers with treatment. Design: A pair-matched, 2-treatment-arm, group-randomized design in 10 family practice clinics in a single metropolitan area. Five clinics were randomized to the AAC (intervention) and 5 to the AAR (control) conditions. In both conditions, clinic staff were trained to assess and record the smoking status of all patients at all visits in the electronic health record, and smokers were given brief advice to quit. In the AAC clinics, the names and telephone numbers of smokers who agreed to be connected were sent electronically to the quitline daily, and patients were called proactively by the quitline within 48 hours. In the AAR clinics, smokers were offered a quitline referral card and encouraged to call on their own. All data were collected from February 8 through December 27, 2011. Setting: Ten clinics in Houston, Texas. Participants: Smoking status assessments were completed for 42,277 patients; 2052 unique smokers were identified at AAC clinics, and 1611 smokers were identified at AAR clinics. Interventions: Linking smokers with quitline-delivered treatment. Main Outcome Measure: Impact was based on the RE-AIM (Reach, Efficacy, Adoption, Implementation, and Maintenance) conceptual framework and defined as the proportion of all identified smokers who enrolled in treatment. Results: In the AAC clinics, 7.8% of all identified smokers enrolled in treatment vs 0.6% in the AAR clinics (t4 = 9.19 [P < .001]; odds ratio, 11.60 [95% CI, 5.53-24.32]), a 13-fold increase in the proportion of smokers enrolling in treatment. Conclusions And Relevance: The system changes implemented in the AAC approach could be adopted broadly by other health care systems and have tremendous potential to reduce tobacco-related morbidity and mortality.
Eliminating Tuberculosis One Neighborhood at a Time.
Cegielski JP, Griffith DE, McGaha PK, Wolfgang M, Robinson CB, Clark PA, Hassell WL, Robison VA, Walker KP, Wallace C.
Am J Public Health. 2013;103:1292–1300
Objectives. We evaluated a strategy for preventing tuberculosis (TB) in communities most affected by it. Methods. In 1996, we mapped reported TB cases (1985–1995) and positive tuberculin skin test (TST) reactors (1993–1995) in Smith County, Texas. We delineated the 2 largest, densest clusters, identifying 2 highest-incidence neighborhoods (180 square blocks, 3153 residents). After extensive community preparation, trained health care workers went door-to-door offering TST to all residents unless contraindicated. TST-positive individuals were escorted to a mobile clinic for radiography, clinical evaluation, and isoniazid preventive treatment (IPT) as indicated. To assess long-term impact, we mapped all TB cases in Smith County during the equivalent time period after the project. Results. Of 2258 eligible individuals, 1291 (57.1%) were tested, 229 (17.7%) were TST positive, and 147 were treated. From 1996 to 2006, there were no TB cases in either project neighborhood, in contrast with the preintervention decade and the continued occurrence of TB in the rest of Smith County. Conclusions. Targeting high-incidence neighborhoods for active, communitybased screening and IPT may hasten TB elimination in the United States.
Investigation of a Chlamydia pneumoniae Outbreak in a Federal Correctional Facility in Texas.
Conklin L, Adjemian J, Loo J, Mandal S, Davis C, Parks S, Parsons T, McDonough B, Partida J, Thurman K, Diaz MH, Benitez A, Pondo T, Whitney CG, Winchell JM, Kendig N, Van Beneden C.
Clin Infect Dis. 2013 May 30. [Epub ahead of print]
Background. Chlamydia pneumoniae illness is poorly characterized, particularly as a sole causative pathogen. We investigated a C. pneumoniae outbreak at a federal correctional facility. Methods. We identified inmates with acute respiratory illness (ARI) from November 1, 2009 - February 24, 2010 through clinic self-referral and active case-finding. We tested oropharyngeal and/or nasopharyngeal swabs for C. pneumoniae by quantitative polymerase chain reaction (qPCR) and sera by microimmunofluorescence. Cases were inmates with ARI and radiologically-confirmed pneumonia, positive qPCR, or serological evidence of recent infection. Swabs from 7 acutely ill inmates were tested for 18 respiratory pathogens using qPCR TaqMan array cards (TAC). Follow-up swabs from case-patients were collected for up to 8 weeks. Results. Among 33 self-referred and 226 randomly selected inmates, 52 (20.1%) met case definition; 4 were confirmed by radiologically-confirmed pneumonia only, 9 by qPCR only, 17 by serology only, and 22 by both qPCR and serology. The prison attack rate was 10.4% (95% CI: 7.0, 13.8%). White inmates and residents of housing unit Y were at highest risk. TAC testing detected C. pneumoniae in 4 (57%) inmates; no other causative pathogens were identified. Among 40 inmates followed prospectively, C. pneumoniae was detected for up to 8 weeks. Thirteen (52%) of 25 inmates treated with azithromycin continued to be qPCR positive >2 weeks after treatment. Conclusions. C. pneumoniae was the causative pathogen of this outbreak. Higher risk among certain groups suggests social interaction contributed to transmission. Persistence of C. pneumoniae in the oropharynx creates challenges for outbreak control measures.
Impact of 2012 West Nile virus outbreak on pesticide exposures reported to Texas poison centers. (No abstract available.)
Forrester MB, Gardner M.
Texas Public Health Journal 2013;65(2):11-13.
Cancer Screenings throughout Texas, 2008 and 2010 Behavioral Risk Factor Surveillance System.
Cook M, Maynard W, Wyatt S, Garcia B.
Texas Public Health Journal. Winter 2013;65(1):8-13.
The article presents a study on the monitoring and screening of cancer in Texas in 2008 and 2010. It looks into the establishment of the Cancer Prevention Research Institute of Texas (CPRIT) and its effort to increase evidence-based screening for cancers of the breast, cervix, and colon and rectum. It explores the estimates of screening rates in the state.
Comparison of Pediatric Exposures to Concentrated "Pack" and Traditional Laundry Detergents.
Pediatr Emerg Care 2013;29:482-486.
Objectives: Pediatric exposures to concentrated laundry detergent packs may result in serious adverse effects. This study compared pediatric exposures to laundry detergent packs and traditional laundry detergents. Methods: Cases were exposures among patients 5 years or younger to laundry detergent packs during January to June 2012 and traditional laundry detergents during January to December 2011 reported to Texas poison centers. Comparisons between the 2 types of products were made for various variables. Results: Of 187 laundry detergent pack and 452 traditional laundry detergent exposures, the patient was already at or en route to a health care facility in 21.4% of the laundry detergent pack and 9.3% of the traditional laundry detergent exposures. Of those exposures where the poison center could potentially influence where the patient was managed, 23.8% of laundry detergent pack and 3.7% of traditional laundry detergent exposures were referred to health care facilities. Potentially serious outcomes were reported in 12.3% of laundry detergent pack and 2.4% of traditional laundry detergent exposures. The most commonly reported clinical effects in laundry detergent pack and traditional laundry detergent exposures were vomiting (54.5% vs 17.0%), cough (11.2% vs 2.2%), ocular irritation (7.0% vs 6.4%), red eye (7.0% vs 5.3%), nausea (7.0% vs 2.7%), and oral irritation (7.0% vs 2.2%). Conclusions: Pediatric exposures to laundry detergent packs were more likely to be managed at a health care facility. Moreover, the laundry detergent pack exposures were more likely to result in serious outcomes and involve the most common clinical effects.
National Outbreak of Type A Foodborne Botulism Associated with a Widely Distributed Commercially Canned Hot Dog Chili Sauce.
Juliao PC, Maslanka S, Dykes J, Gaul L, Bagdure S, Granzow-Kibiger L, Salehi E, Zink D, Neligan RP, Barton-Behravesh C, Lúquez C, Biggerstaff M, Lynch M, Olson C, Williams I, Barzilay EJ.
Clin Infect Dis. 2013 Feb;56(3):376-82.
A type A botulism outbreak was associated with commercially canned food; it is the first botulism outbreak in the United States involving a commercial cannery in >30 years. Because of possible widespread distribution of the implicated product, this outbreak was a major public health concern. Background: On 7 and 11 July 2007, health officials in Texas and Indiana, respectively, reported 4 possible cases of type A foodborne botulism to the US Centers for Disease Control and Prevention. Foodborne botulism is a rare and sometimes fatal illness caused by consuming foods containing botulinum neurotoxin. Methods: Investigators reviewed patients’ medical charts and food histories. Clinical specimens and food samples were tested for botulinum toxin and neurotoxin-producing Clostridium species. Investigators conducted inspections of the cannery that produced the implicated product. Results: Eight confirmed outbreak associated cases were identified from Indiana (n = 2), Texas (n = 3), and Ohio (n = 3). Botulinum toxin type A was identified in leftover chili sauce consumed by the Indiana patients and 1 of the Ohio patients. Cannery inspectors found violations of federal canned-food regulations that could have led to survival of Clostridium botulinum spores during sterilization. The company recalled 39 million cans of chili. Following the outbreak, the US Food and Drug Administration inspected other canneries with similar canning systems and issued warnings to the industry about the danger of C. botulinum and the importance of compliance with canned food manufacturing regulations. Conclusions: Commercially produced hot dog chili sauce caused these cases of type A botulism. This is the first US foodborne botulism outbreak involving a commercial cannery in >30 years. Sharing of epidemiologic and laboratory findings allowed for the rapid identification of implicated food items and swift removal of potentially deadly products from the market by US food regulatory authorities.
Emergence of Autochthonous Cutaneous Leishmaniasis in Northeastern Texas and Southeastern Oklahoma.
Clarke CF, Bradley KK, Wright JH, Glowicz J.
Am J Trop Med Hyg. 2013 Jan;88(1):157-61.
Autochthonous human cases of leishmaniasis in the United States are uncommon. We report three new cases of cutaneous leishmaniasis and details of a previously reported case, all outside the known endemic range in Texas. Surveys for enzootic rodent reservoirs and sand fly vectors were conducted around the residences of three of the case-patient during the summer of 2006; female Lutzomyia anthophora sand flies were collected at a north Texas and southeast Oklahoma residence of a case-patient, indicating proximity of a suitable vector. Urban sprawl, climatologic variability, or natural expansion of Leishmania mexicana are possible explanations for the apparent spread to the north and east. Enhanced awareness among healthcare providers in the south central region of the United States is important to ensure clinical suspicion of leishmaniasis, diagnosis, and appropriate patient management.
Disparities in the Treatment and Outcomes of Lung Cancer among HIV-infected People in Texas.
Suneja G, Shiels MS, Melville SK, Williams MA, Rengan R, Engels EA.
AIDS. 2013 Jan 28;27(3):459-68.
Objectives:: HIV-infected people have elevated risk for lung cancer and higher mortality following cancer diagnosis than HIV-uninfected individuals. It is unclear whether HIV-infected people with lung cancer receive similar cancer treatment as HIV-uninfected people. Design/Methods: We studied adults 18+ years old with lung cancer reported to the Texas Cancer Registry (N = 156,930) from 1995-2009. HIV status was determined by linkage with the Texas enhanced HIV/AIDS Reporting System. For non-small cell lung cancer (NSCLC) cases, we identified predictors of cancer treatment using logistic regression. We used Cox regression to evaluate effects of HIV and cancer treatment on mortality. Results: Compared with HIV-uninfected lung cancer cases (N = 156,593), HIV-infected lung cancer cases (N = 337) were more frequently young, non-Hispanic black, male, and with distant stage disease. HIV-infected NSCLC cases less frequently received cancer treatment than HIV-uninfected cases (60.3% vs. 77.5%; odds ratio 0.39, 95% confidence interval [CI] 0.30-0.52, after adjustment for diagnosis year, age, sex, race, stage, and histologic subtype). HIV infection was associated with higher lung cancer-specific mortality (hazard ratio [HR] 1.34, 95%CI 1.15-1.56, adjusted for demographics and tumor characteristics). Inclusion of cancer treatment in adjusted models slightly attenuated the effect of HIV on lung cancer-specific mortality (HR 1.25; 95%CI 1.06-1.47). Also, there was a suggestion that HIV was more strongly associated with mortality among untreated than among treated cases (adjusted HR 1.32 vs. 1.16, p-interaction = 0.34). Conclusion: HIV-infected NSCLC cases were less frequently treated for lung cancer than HIV-uninfected cases, which may have affected survival.
From Model to Action: Using a System Dynamics Model of Chronic Disease Risks to Align Community Action.
Loyo HK, Batcher C, Wile K, Huang P, Orenstein D, Milstein B.
Health Promot Pract. 2013 Jan;14(1):53-61.
Health planners in Austin, Texas, are using a System Dynamics Model of Cardiovascular Disease Risks (SD model) to align prevention efforts and maximize the effect of limited resources. The SD model was developed using available evidence of disease prevalence, risk factors, local contextual factors, resulting health conditions, and their impact on population health. Given an interest in understanding opportunities for upstream health protection, the SD model focused on the portion of the population that has never had a cardiovascular event. Leaders in Austin used this interactive simulation model as a catalyst for convening diverse stakeholders in thinking about their strategic directions and policy priorities. Health officials shared insights from the model with a range of organizations in an effort to align actions and leverage assets in the community to promote healthier conditions for all. This article summarizes the results from several simulated intervention scenarios focusing specifically on conditions in East Travis County, an area marked by higher prevalence of adverse living conditions and related chronic diseases. The article also describes the formation of a new Chronic Disease Prevention Coalition in Austin, along with shifts in its members perceived priorities for intervention both before and after interactions with the SD model.
West Nile Virus Infection among Humans, Texas, USA, 2002-2011.
Nolan M, Schuermann J, Murray K.
Emerg Infect Dis. 2013 Jan;19(1):137-9.
We conducted an epidemiologic analysis to document West Nile virus infections among humans in Texas, USA, during 2002-2011. West Nile virus has become endemic to Texas; the number of reported cases increased every 3 years. Risk for infection was greatest in rural northwestern Texas, where Culex tarsalis mosquitoes are the predominant mosquito species.
Pediatric Insecticide Chalk Exposures Reported to Texas Poison Centers.
Hum Exp Toxicol 2013;32:554-8.
The pesticide Miraculous Insecticide Chalk is illegal in the United States but can be obtained through a variety of sources. Because it is a stick similar in appearance to common blackboard chalk, children might play with it and put it in their mouths. All Miraculous Insecticide Chalk exposures involving children 5 years or younger reported to Texas poison centers during 2000-2010 were identified. The distribution by selected demographic and clinical factors was calculated. Of the total 188 exposures, the mean age was 1.5 years (range 6 months-5 years) and 60.6% were male. Ingestions were reported in 97.3% of the exposures, and these were reported to involve at most one stick of the chalk. The lowest exposure rates per 100,000 population of 5 years or younger were reported in the Public Health Regions in northern and eastern Texas (0.00-2.30) and the highest rates in the Public Health Regions in southern and western Texas (19.08-39.50). Of the 187 exposures not involving other substances, 96.8% were known or expected to result in at most minor effects, and 71.1% were managed on site (at residence).
Reporting of Bedbug Treatment Exposures to Texas Poison Centres
Forrester MB, Prosperie S.
Public Health. 2013 Mar 12. [Epub ahead of print] (No abstract available.)
Adolescent Synthetic Cathinone Exposures Reported to Texas Poison Centers.
Pediatr Emerg Care 2013 [Epub ahead of print]
Objectives: This study describes the pattern of adolescent synthetic cathinone exposures reported to a large, statewide poison center system. Methods: Synthetic cathinone exposures among patients younger than 20 years reported to Texas poison centers during 2010 to 2011 were identified. The distribution of exposures by various demographic and clinical factors was determined. Results: For 51 adolescent exposures, the mean age was 17.5 years (range, 12-19 years). The exposure was by inhalation in 66.7% of the cases and 60.8% involved male patients. The exposure site was the patient's own or another residence in 58.8% of the cases. The patient was already at or en route to a health care facility in 76.5% of the cases, and the medical outcome was known or suspected to be serious in 74.5%. The most frequently reported adverse clinical effects were agitation/irritability (43.1%), tachycardia (37.3%), drowsiness/lethargy (13.7%), hallucinations (9.8%), fever (9.8%), vomiting (9.8%), and hypertension (7.8%). Conclusions: Adolescent synthetic cathinone exposures reported to Texas poison centers were more likely to have occurred by inhalation. The adolescents were more likely to be male. The exposures more often occurred at the patient's own residence and were managed at a health care facility with a serious outcome. This pattern of exposures was similar to that observed among adults.