Multisystem Inflammatory Syndrome in Children (MIS-C)

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This page contains general information about multisystem inflammatory syndrome in children (MIS-C), a rare but serious condition associated with COVID-19. For MIS-C case data reported to Texas DSHS, see our MIS-C data page:
MIS-C Data

On this page:


Illness Overview

Multisystem inflammatory syndrome in children (MIS-C) is a rare but serious condition requiring hospitalization. It occurs in children and young adults under 21 years of age. MIS-C is related to SARS-CoV-2, the virus that causes COVID‑19. Children with MIS-C have inflammation and clinically severe illness in two or more organs, including the:

  • Heart
  • Lungs
  • Kidneys
  • Skin
  • Blood
  • Gastrointestinal organs
  • Brain
  • Eyes

MIS-C probably results from the immune system’s response to SARS-CoV-2. Children with MIS-C have been infected with the virus or exposed to someone with COVID-19. A child may have been infected without any COVID-19 symptoms or without the child or caregiver knowing about the infection (for example, the child was not tested for COVID-19).

Researchers are still learning why some children develop MIS-C after infection and why others do not.

Refer to the CDC website for more information for parents and healthcare providers on MIS-C:


What Texas Is Doing About MIS-C

Texas DSHS has a team dedicated to monitoring MIS-C cases in Texas. This team works closely with regional and local health departments to detect and investigate MIS-C cases. The team also works closely with CDC to learn more about this condition.


Reporting MIS-C Cases in Texas

Hospitals and other healthcare facilities that treat patients with MIS-C should promptly report the case to their local health department. When reporting the case, please be prepared to provide the following patient information:

  • Demographics (face sheet)
  • History and physical, progress notes pertaining to MIS-C visit
  • Laboratory results pertaining to MIS-C, including any COVID-19 tests, blood tests, urine tests, and bacterial cultures that were performed
  • Discharge summary, if available

The local health department will investigate the case to determine if MIS-C case criteria is met and notify Texas DSHS. Contact your local health department with any questions about MIS-C or how to report MIS-C.


Why Reporting MIS-C Is Important

MIS-C is a new and rare condition characterized by clinically severe illness. It is important to report suspected cases of MIS-C to your local health department so we can better understand the causes, risk factors, and outcomes of the condition for prevention and treatment and to keep healthcare providers and the public informed.

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This page is being updated as new information becomes available.

Last updated May 2, 2022